Dr. Terrible's House of Horrible (2001)

S1E3 Curse of the Blood of the Lizard of Doom

Dr. Donald Baxter, on a quest to find a remedy for everyday burns, experiments with a groundbreaking lizard serum. However, the unintended consequences of his actions lead to a dramatic transformation, turning him into a colossal reptile. As he grapples with his new identity, the challenges of managing his powers and the repercussions of his experiment unfold, plunging him into a chaotic struggle.