The Muppet Show (1976)

S1E1 Joel Grey

Fozzie is determined to create a new comedy routine featuring jokes on every conceivable topic, but his relentless practice begins to irritate those around him. At last, the moment arrives for him to perform, and he invites the audience to shout out any word. Statler and Waldorf seize the opportunity, challenging him by shouting, "Amoeba!"